Freeway's finale
Posted: Tue Mar 01, 2016 5:19 pm
Reposting here for those who aren't on the UDBB FB group.
Freeway's finale. I heard back from UC Davis on the postmortem pathology results. He always was the best teaching case. I'm so glad I took him to UCD at the end, I may no longer have the horse, but if in losing the horse, someone can learn something, that's all I can ask for. Maybe he'll be in a veterinary textbook someday.
"Hi Sue,
I've attached the final results for Freeway- he continues to teach us. The histopathologists described a tumor that has not been reported in horses before.
I can't thank you enough for supporting the hospital every step of the way. Please let me know is there are any questions that you have, or if there is anything that I can help you with.
SIGNIFICANT FINAL DIAGNOSES:
RIGHT MANDIBLE: AMELOBLASTIC CARCINOSARCOMA (SEE COMMENT)
ADDENDUM:
The rare and interesting neoplastic mandibular mass demonstrates multiple malignant histologic features, namely a) presumed malignant neoplastic odontogenic epithelium characterized by palisading ameloblasts with nuclei polarized away from basement membrane occasionally lining odontogenic matrix or arranged in plexiform ribbons, and b) a malignant neoplastic mesenchymal cell population that is multifocally closely associated with osteoidal matrix (neoplasm associated osteoid). This latter feature is highly suggestive of osteosarcoma. The neoplastic cell populations have patchy immunoreactivity with both pancytokeratin and vimentin. No classification in the veterinary literature is currently available to characterize/categorize this neoplasm. However, given that there are both malignant epithelial and mesenchymal components, this tumor is most consistent with an ameloblastic carcinosarcoma."
Freeway's finale. I heard back from UC Davis on the postmortem pathology results. He always was the best teaching case. I'm so glad I took him to UCD at the end, I may no longer have the horse, but if in losing the horse, someone can learn something, that's all I can ask for. Maybe he'll be in a veterinary textbook someday.
"Hi Sue,
I've attached the final results for Freeway- he continues to teach us. The histopathologists described a tumor that has not been reported in horses before.
I can't thank you enough for supporting the hospital every step of the way. Please let me know is there are any questions that you have, or if there is anything that I can help you with.
SIGNIFICANT FINAL DIAGNOSES:
RIGHT MANDIBLE: AMELOBLASTIC CARCINOSARCOMA (SEE COMMENT)
ADDENDUM:
The rare and interesting neoplastic mandibular mass demonstrates multiple malignant histologic features, namely a) presumed malignant neoplastic odontogenic epithelium characterized by palisading ameloblasts with nuclei polarized away from basement membrane occasionally lining odontogenic matrix or arranged in plexiform ribbons, and b) a malignant neoplastic mesenchymal cell population that is multifocally closely associated with osteoidal matrix (neoplasm associated osteoid). This latter feature is highly suggestive of osteosarcoma. The neoplastic cell populations have patchy immunoreactivity with both pancytokeratin and vimentin. No classification in the veterinary literature is currently available to characterize/categorize this neoplasm. However, given that there are both malignant epithelial and mesenchymal components, this tumor is most consistent with an ameloblastic carcinosarcoma."